Caffeine and Adderall


As a leading producer of nootropic supplements, brain health and science guides everything we do. Our purpose is to provide the best nootropics for focus on the market. 


Caffeine is by far the most widely used psychoactive drug in the world, with approximately 90% of  the population (including children) in the United States regularly consuming caffeine-containing  drinks. Common natural sources of caffeine include coffee, tea, cacao, kola, guarana, and yerba  mate. Two other molecules with similar effects to caffeine are Theophylline (found in tea) and  Theobromine (found in cacao). Caffeine is a powerful stimulant drug that increases wakefulness  and alertness and increases your heart rate and blood pressure. 

Caffeine is structurally similar to  adenosine, a neurotransmitter that is the “A” in ATP (the energy currency that powers your body). Caffeine is so similar to adenosine that it is able to bind to adenosine receptors, but caffeine is dissimilar enough that it does not trigger the adenosine receptors, it just prevents adenosine from binding and triggering the receptors. Adenosine operates as an inhibitory neurotransmitter that slows your heart rate, dilates your blood vessels, and decreases neuronal excitability in your brain. By blocking these effects, Caffeine has the opposite effects on your brain and body. 

By blocking adenosine receptors, caffeine makes dopamine more effective in activating certain dopamine receptors. Over time this can wear down and damage those dopamine receptors. Caffeine  also triggers an increase in dopamine release in the nucleus accumbens (the brain’s reward center),  which is the reason caffeine is pleasurable to ingest and addictive. 

From a nutritional perspective, it is advisable for caffeine drinkers to help replenish their dopamine  levels by supplementing with N-Acetyl L-Tyrosine and to help repair damage to dopamine receptors by supplementing with Uridine 5’-Monophosphate.


Adderall is a mixture of four different salt forms of amphetamine. Adderall cannot activate receptors in your brain directly, but instead functions by stimulating the release of Dopamine and Norepinephrine in your brain. At low doses, Adderall produces modest yet noticeable improvements  in cognition, working/short-term memory, long-term memory, focus and attention, wakefulness,  drive and motivation. At low doses, Adderall’s effects are very similar to those of cocaine (though  cocaine’s effects are of much shorter duration). 

Adderall is generally safe when used in correct oral dosage regimes, but can also have a number of  serious and less serious side effects. Adderall, and amphetamines generally, trigger a release of Norepinephrine in the peripheral nervous system, which leads to an increase in heart rate and blood  pressure. This is not generally an issue for young, healthy individuals (unless they are engaged in  strenuous exercise or sports activities), but can create serious cardiovascular issues in older and less  healthy individuals. Psychologically, Adderall can cause compulsive behaviors, nervous behaviors,  anxiety, irritability, psychosis, loss of appetite, and insomnia. 

The Adderall amphetamine molecules are structurally very similar to Phenylethylamine, which  occurs naturally in your body and is found in foods like cacao (where it is better known as the “love  molecule”). Phenylethylamine, especially when potentiated by Caffeine, has many of the same positive effects as Adderall, but without the negative side effects. 

From a nutritional perspective, it is advisable for Adderall users to help replenish their Dopamine  and Norepinephrine levels by supplementing with N-Acetyl L-Tyrosine and to help repair damage  to Dopamine receptors by supplementing with Uridine 5’-Monophosphate. There is some evidence  that Zinc supplementation may reduce the minimum effective dose of Adderall.

Whether you’re just starting to discover nootropics, or you’ve experienced other nootropic brands and are considering new options, we invite you to explore our daytime nootropic Awaken Gold and our nighttime nootropic Mind:Restore. We designed these to be the cleanest and most effective nootropics available.

If you have questions about our products or want to share your experiences with them, please Contact Us.

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